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Ssc-mir-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene.
Yuan W, Qin H, Bi H, Zhao D, Zhang Y, Chen W. Yuan W, et al. BMC Genomics. 2023 Jul 1;24(1):369. doi: 10.1186/s12864-023-09451-w. BMC Genomics. 2023. PMID: 37393242 Free PMC article.

RESULTS: 17 miRNAs and 1,230 genes were significantly differentially expressed (P < 0.05) in the black and white skin tissues of Jianbai Xiang pigs. miRNA-221-3p was identified as a candidate miRNA for melanin formation and its target gene, TYRP1, was selected. The T

…

RESULTS: 17 miRNAs and 1,230 genes were significantly differentially expressed (P < 0.05) in the black and white skin tissues of Jianbai

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Genomic anatomy of the Tyrp1 (brown) deletion complex.
Smyth IM, Wilming L, Lee AW, Taylor MS, Gautier P, Barlow K, Wallis J, Martin S, Glithero R, Phillimore B, Pelan S, Andrew R, Holt K, Taylor R, McLaren S, Burton J, Bailey J, Sims S, Squares J, Plumb B, Joy A, Gibson R, Gilbert J, Hart E, Laird G, Loveland J, Mudge J, Steward C, Swarbreck D, Harrow J, North P, Leaves N, Greystrong J, Coppola M, Manjunath S, Campbell M, Smith M, Strachan G, Tofts C, Boal E, Cobley V, Hunter G, Kimberley C, Thomas D, Cave-Berry L, Weston P, Botcherby MR, White S, Edgar R, Cross SH, Irvani M, Hummerich H, Simpson EH, Johnson D, Hunsicker PR, Little PF, Hubbard T, Campbell RD, Rogers J, Jackson IJ. Smyth IM, et al. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3704-9. doi: 10.1073/pnas.0600199103. Epub 2006 Feb 27. Proc Natl Acad Sci U S A. 2006. PMID: 16505357 Free PMC article.
Chromosome deletions in the mouse have proven invaluable in the dissection of gene function. The brown deletion complex comprises >28 independent genome rearrangements, which have been used to identify several functional loci on chromosome 4 required for normal e …
Chromosome deletions in the mouse have proven invaluable in the dissection of gene function. The brown deletion complex comprises &gt …
Homozygous deletions within human chromosome band 9p21 in melanoma.
Fountain JW, Karayiorgou M, Ernstoff MS, Kirkwood JM, Vlock DR, Titus-Ernstoff L, Bouchard B, Vijayasaradhi S, Houghton AN, Lahti J, et al. Fountain JW, et al. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10557-61. doi: 10.1073/pnas.89.21.10557. Proc Natl Acad Sci U S A. 1992. PMID: 1438246 Free PMC article.
Genetic studies have implicated the early involvement of a gene on chromosome arm 9p in the development of cutaneous melanoma. We have performed loss-of-heterozygosity studies to confirm these original findings and identify the most frequently rearranged or deleted region …
Genetic studies have implicated the early involvement of a gene on chromosome arm 9p in the development of cutaneous melanoma. We hav …
Melanotic Xp11 translocation renal cancer: a case with PSF-TFE3 gene fusion and up-regulation of melanogenetic transcripts.
Chang IW, Huang HY, Sung MT. Chang IW, et al. Am J Surg Pathol. 2009 Dec;33(12):1894-901. doi: 10.1097/PAS.0b013e3181ba7a5f. Am J Surg Pathol. 2009. PMID: 19809274
Up-regulations of melanogenesis-associated regulators, including microphthalmia-associated transcription factor, tyrosinase (TYR), and tyrosinase-related protein 1 (TYRP1), were identified in the tumor by semiquantitative reverse transcription-polymerase chain reaction. .. …
Up-regulations of melanogenesis-associated regulators, including microphthalmia-associated transcription factor, tyrosinase (TYR), and tyros …
Mutations in the MATP gene in five German patients affected by oculocutaneous albinism type 4.
Rundshagen U, Zühlke C, Opitz S, Schwinger E, Käsmann-Kellner B. Rundshagen U, et al. Hum Mutat. 2004 Feb;23(2):106-110. doi: 10.1002/humu.10311. Hum Mutat. 2004. PMID: 14722913
OCA3, also known as rufous/red albinism, is caused by mutations in the TYRP1 gene, which encodes the tyrosinase-related protein 1. Recently, OCA4 was described as a new form of OCA in a single patient with a splice site mutation in the MATP gene (or AIM1), the human orthol …
OCA3, also known as rufous/red albinism, is caused by mutations in the TYRP1 gene, which encodes the tyrosinase-related protein 1. Re …
EWS-CREB1: a recurrent variant fusion in clear cell sarcoma--association with gastrointestinal location and absence of melanocytic differentiation.
Antonescu CR, Nafa K, Segal NH, Dal Cin P, Ladanyi M. Antonescu CR, et al. Clin Cancer Res. 2006 Sep 15;12(18):5356-62. doi: 10.1158/1078-0432.CCR-05-2811. Clin Cancer Res. 2006. PMID: 17000668
The Affymetrix gene expression data available in one case showed lower expression of the melanocytic genes MITF, TYR, and TYRP1, compared with four EWS-ATF1-positive CCSs of non-gastrointestinal origin. ...
The Affymetrix gene expression data available in one case showed lower expression of the melanocytic genes MITF, TYR, and TYRP1, comp …